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| 平台 | ROM名称 | 游戏名称 | 中文名称 | 补充 |
|---|---|---|---|---|
| gb | Shin Nihon Pro Wrestling - Toukon Sanjuushi (Japan) | Shin Nihon Pro Wrestling - Toukon Sanjuushi (Japan) | 斗魂三铳士 | |
| gb | Shin SD Gundam Gaiden - Knight Gundam Monogatari (Japan) (SGB Enhanced) | Shin SD Gundam Gaiden - Knight Gundam Monogatari (Japan) (SGB Enhanced) | SD高达外传-骑士物语 | |
| gb | Shinri Game 2, The - Oosaka Hen (Japan) | Shinri Game 2, The - Oosaka Hen (Japan) | 心理问答2 | |
| gb | Shinri Game, The (Japan) | Shinri Game, The (Japan) | 心理问答 | |
| gb | Shinseiki GPX - Cyber Formula (Japan) | Shinseiki GPX - Cyber Formula (Japan) | 新世纪GPX-高智能方程式赛车 | |
| gb | Shippo de Bun (Japan) | Shippo de Bun (Japan) | 鳄鱼龙 | |
| gb | Shippuu! Iron Leaguer (Japan) | Shippuu! Iron Leaguer (Japan) | 疾风无敌银堡垒 | |
| gb | Shisenshou - Match-Mania (Japan) | Shisenshou - Match-Mania (Japan) | 四川省 | |
| gb | Shougi (Japan) | Shougi (Japan) | 将棋 | |
| gb | Shougi Saikyou (Japan) (Rev 1) (SGB Enhanced) | Shougi Saikyou (Japan) (Rev 1) (SGB Enhanced) | 最强将棋 | |
| gb | Shougi Saikyou (Japan) (SGB Enhanced) | Shougi Saikyou (Japan) (SGB Enhanced) | 最强将棋 | |
| gb | Shounen Ashibe - Yuuenchi Panic (Japan) | Shounen Ashibe - Yuuenchi Panic (Japan) | 少年西贝大冒险 | |
| gb | Shuyaku Sentai Irem Fighter (Japan) | Shuyaku Sentai Irem Fighter (Japan) | 主役战队 | |
| gb | Side Pocket (World) | Side Pocket (World) | 花式撞球世界 | |
| gb | Simpsons, The - Bart & the Beanstalk (USA, Europe) | Simpsons, The - Bart & the Beanstalk (USA, Europe) | 辛普森-巴特与豆茎 | |
| gb | Simpsons, The - Bart no Jack to Mame no Ki (Japan) | Simpsons, The - Bart no Jack to Mame no Ki (Japan) | 辛普森一家-巴特与豆茎 | |
| gb | Simpsons, The - Bart vs. the Juggernauts (USA, Europe) | Simpsons, The - Bart vs. the Juggernauts (USA, Europe) | 辛普森一家巴特与魔豆 | |
| gb | Simpsons, The - Itchy & Scratchy - Miniature Golf Madness (USA, Europe) | Simpsons, The - Itchy & Scratchy - Miniature Golf Madness (USA, Europe) | 辛普森一家-疯狂的迷你高尔夫 | |
| gb | Skate or Die - Bad 'N Rad (Europe) | Skate or Die - Bad 'N Rad (Europe) | 生死滑板 | |
| gb | Skate or Die - Bad 'N Rad (USA) | Skate or Die - Bad 'N Rad (USA) | 生死滑板 | |
| gb | Skate or Die - Tour de Thrash (USA) | Skate or Die - Tour de Thrash (USA) | 生死滑板2 | |
| gb | Small Soldiers (USA, Europe) (SGB Enhanced) | Small Soldiers (USA, Europe) (SGB Enhanced) | 晶兵总动员 | |
| gb | Smurfs Nightmare, The (Europe) (En,Fr,De,Es) | Smurfs Nightmare, The (Europe) (En,Fr,De,Es) | 蓝精灵梦魇 | |
| gb | Smurfs Travel the World, The (Europe) (En,Fr,De,Es) | Smurfs Travel the World, The (Europe) (En,Fr,De,Es) | 蓝精灵环游世界 | |
| gb | Smurfs, The (Europe) (En,Fr,De,Es) | Smurfs, The (Europe) (En,Fr,De,Es) | 蓝精灵 | |
| gb | Smurfs, The (USA, Europe) (En,Fr,De) (Rev 1) (SGB Enhanced) | Smurfs, The (USA, Europe) (En,Fr,De) (Rev 1) (SGB Enhanced) | 蓝精灵 | |
| gb | Sneaky Snakes (USA, Europe) | Sneaky Snakes (USA, Europe) | 双蛇城 | |
| gb | Snoopy - Magic Show (Japan) | Snoopy - Magic Show (Japan) | 史努比-魔术表演 | |
| gb | Snoopy no Hajimete no Otsukai (Japan) (SGB Enhanced) | Snoopy no Hajimete no Otsukai (Japan) (SGB Enhanced) | 史努比之路 | |
| gb | Snoopy's Magic Show (USA, Europe) | Snoopy's Magic Show (USA, Europe) | 史努比魔术表演 | |
| gb | Snow Bros. Jr. (Japan) | Snow Bros. Jr. (Japan) | 雪人兄弟 | |
| gb | Snow Brothers (Europe) | Snow Brothers (Europe) | 雪人兄弟 | |
| gb | Snow Brothers (USA) | Snow Brothers (USA) | 雪人兄弟 | |
| gb | Soccer (Europe, Australia) (En,Fr,De) (SGB Enhanced) | Soccer (Europe, Australia) (En,Fr,De) (SGB Enhanced) | 足球 | |
| gb | Soccer (Japan) | Soccer (Japan) | 足球 | |
| gb | Soccer Boy (Japan) (En) | Soccer Boy (Japan) (En) | 足球少年 | |
| gb | Soccer Mania (USA) | Soccer Mania (USA) | 疯狂足球 | |
| gb | SolarStriker (World) | SolarStriker (World) | 太阳风暴世界 | |
| gb | Soldam (Japan) | Soldam (Japan) | 苏登益智方块 | |
| gb | Solitaire (Japan) | Solitaire (Japan) | 纸牌游戏 | |
| gb | Solitaire FunPak (USA, Europe) | Solitaire FunPak (USA, Europe) | 纸牌游戏 | |
| gb | Solomon's Club (Europe) | Solomon's Club (Europe) | 所罗门俱乐部 | |
| gb | Solomon's Club (Japan) | Solomon's Club (Japan) | 所罗门俱乐部 | |
| gb | Solomon's Club (USA) | Solomon's Club (USA) | 所罗门俱乐部 | |
| gb | Soreyuke! Speedy Gonzales (Japan) | Soreyuke! Speedy Gonzales (Japan) | 索尼克6 | |
| gb | Soreyuke!! Kid (Japan) | Soreyuke!! Kid (Japan) | 飞飞鼠 | |
| gb | Soukoban (Japan) | Soukoban (Japan) | 仓库番 | |
| gb | Soukoban 2 (Japan) | Soukoban 2 (Japan) | 仓库番2 | |
| gb | Space Invaders (Europe) (SGB Enhanced) | Space Invaders (Europe) (SGB Enhanced) | 太空入侵者 | |
| gb | Space Invaders (Japan) | Space Invaders (Japan) | 太空入侵者 |